Structure of PDB 8e6s Chain D

Receptor sequence
>8e6sD (length=1330) Species: 9606 (Homo sapiens) [Search protein sequence]
SSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQ
GTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMT
QHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGG
SHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGS
FPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFI
SEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRV
ADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDI
VRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLA
VAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQ
LKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRLQMH
HVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYK
RSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKIL
KELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVS
EAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLC
MLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF
LCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKK
AALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLR
LMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHN
ERRVDWLFRGAVYHSYLTIFGQIPGYIDGFPEWLTVLLLCLYLLFTNILL
LNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHL
QLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQ
KQRPEQKIEDISNKVDAMVDLLDLDGDSYHVNARHLLYPNCPVTRFPVPN
EKVPWETEFLIYDPPFYTALEPLSTIQYNVVDGLRDRRSFHGPYTVQAGL
PLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLE
VLVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGME
VYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELNRLNSNLHACDSGASI
RWQVVDRRIPLYANHKTLLQKAAAEFGAHY
3D structure
PDB8e6s A unified mechanism for human TRPM2 activation, desensitization and inhibition
ChainD
Resolution4.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR D G175 G176 A177 K178 S210 T275 Y295 G332 G333 P334 G335 T336 M390 G116 G117 A118 K119 S151 T216 Y236 G273 G274 P275 G276 T277 M331
BS02 DAT D L1339 S1340 N1345 S1391 R1433 L1166 S1167 N1172 S1218 R1260
BS03 ZN D C89 C91 H98 C30 C32 H39
BS04 CA D D866 F867 W868 K932 D807 F808 W809 K873
External links
PDB RCSB:8e6s, PDBe:8e6s, PDBj:8e6s
PDBsum8e6s
PubMed
UniProtO94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (Gene Name=TRPM2)

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