Structure of PDB 8e6q Chain D

Receptor sequence
>8e6qD (length=1348) Species: 9606 (Homo sapiens) [Search protein sequence]
QESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKP
HTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIY
HLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWI
ITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIH
PTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRL
EKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEG
SGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKK
IQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQ
LKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLE
NGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPR
LQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLR
SLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALAC
SKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLL
TRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWR
VTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILS
YFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECG
LMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFIL
FCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAI
LIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGFPEWLTVLLLCLYLLFT
NILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFIL
LSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNR
QFQQKQRPEQKIEDISNKVDAMVDLLDLDGDSYHVNARHLLYPNCPVTRF
PVPNEKVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVD
GLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRW
RRNEDGAICRKSIKKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRI
LRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDV
ELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY
3D structure
PDB8e6q A unified mechanism for human TRPM2 activation, desensitization and inhibition
ChainD
Resolution3.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR D T174 G175 A177 K178 N179 Y295 G332 G333 P334 G335 R358 T119 G120 A122 K123 N124 Y240 G277 G278 P279 G280 R303
BS02 APR D L1381 S1382 D1431 R1433 Y1485 L1226 S1227 D1276 R1278 Y1330
External links
PDB RCSB:8e6q, PDBe:8e6q, PDBj:8e6q
PDBsum8e6q
PubMed
UniProtO94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (Gene Name=TRPM2)

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