Structure of PDB 8e5b Chain D

Receptor sequence
>8e5bD (length=948) Species: 9606 (Homo sapiens) [Search protein sequence]
FPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELN
WTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVKIDLYDVRRR
PWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNV
ASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAF
EQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQ
HNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKA
KQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVD
VSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINS
QEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKG
NRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNF
EESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLIN
RVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQ
ENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQ
GKLLKPAVVGIKIDVNSWIENFTKRNSDVMDCVILDDGGFLLMANHDDYT
NQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAASKQSCITEQ
TQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDT
RLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSG
3D structure
PDB8e5b Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D S261 S263 T331 S220 S222 T290
External links
PDB RCSB:8e5b, PDBe:8e5b, PDBj:8e5b
PDBsum8e5b
PubMed36417914
UniProtP54289|CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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