Structure of PDB 8e24 Chain D

Receptor sequence
>8e24D (length=648) Species: 9606 (Homo sapiens) [Search protein sequence]
SSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTGFP
IKGCDDTLVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRK
ESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPT
LHSIVTSFLPHELPLLEGMETSQGQSLGLNAGSEHSGRYRASVESILIFN
SMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHI
MQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNRQFSTSKDV
LNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVS
QSHTATGRITFTEPNIQNVPRDFEIKMPTLADRGMPFSISMRHAFVPFPG
GSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPES
VGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGI
NQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIV
QGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMCPIRGGFFILQLHDE
LLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFD
3D structure
PDB8e24 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
ChainD
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8e24, PDBe:8e24, PDBj:8e24
PDBsum8e24
PubMed36126059
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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