Structure of PDB 8dso Chain D

Receptor sequence
>8dsoD (length=91) Species: 9606 (Homo sapiens) [Search protein sequence]
ISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCD
GGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGR
3D structure
PDB8dso A covalent BTK ternary complex compatible with targeted protein degradation
ChainD
Resolution2.334 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TOO D D303 K305 G312 L313 R314 W316 D320 W329 D43 K45 G52 L53 R54 W56 D60 W69
BS02 ZN D C306 C309 H326 C333 C46 C49 H66 C73
External links
PDB RCSB:8dso, PDBe:8dso, PDBj:8dso
PDBsum8dso
PubMed36864023
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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