Structure of PDB 8dsf Chain D

Receptor sequence
>8dsfD (length=91) Species: 9606 (Homo sapiens) [Search protein sequence]
SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCC
DGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQG
3D structure
PDB8dsf A covalent BTK ternary complex compatible with targeted protein degradation
ChainD
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C306 C309 H326 C333 C47 C50 H67 C74
BS02 TO0 D D303 K305 G312 L313 R314 D320 W329 D44 K46 G53 L54 R55 D61 W70
External links
PDB RCSB:8dsf, PDBe:8dsf, PDBj:8dsf
PDBsum8dsf
PubMed36864023
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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