Structure of PDB 8dey Chain D

Receptor sequence
>8deyD (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
TLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLEL
RTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCS
YKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKD
DSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTS
LCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNL
IGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
3D structure
PDB8dey Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
ChainD
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C323 C326 C391 C394 C253 C256 C321 C324
External links
PDB RCSB:8dey, PDBe:8dey, PDBj:8dey
PDBsum8dey
PubMed36863346
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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