Structure of PDB 8ddx Chain D

Receptor sequence

>8ddxD (length=992) Species: 10090 (Mus musculus)

ISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQ
LELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTG
VIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRI
GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGH
KYSEVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDL
AILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAM
LDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR
DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPK
RPKALKLLGMEDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHG
EEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD
QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTD
MWMGRLRMRKNSGLKVILGILLPPSILSLEFKNGRKIYEFYNAPIVKFWF
YTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSE
PGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCV
NIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVA
RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCQLPPCKTGAW
IVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT
FHERPVLPPPLIIFSHMTMIFQHVCRDYGLKLFITDDELKKVHDFEEQCI
EEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHS

3D structure

• PDB: 8ddx Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
• Chain: D
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	H132 T133 Q134 L135 S136 T138 S161 G300	H4 T5 Q6 L7 S8 T10 S33 G172
BS02	9Z9	D	S1039 W1040	S812 W813
BS03	9Z9	D	M887 Y983	M660 Y756
BS04	PIO	D	W876 F990 K994	W649 F763 K767

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0051262 protein tetramerization
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8ddx, PDBe:8ddx, PDBj:8ddx
• PDBsum: 8ddx
• PubMed: 36283409
• UniProt: Q5F4S7