Structure of PDB 8cvt Chain D

Receptor sequence
>8cvtD (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]
DLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLV
IGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNA
LVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHF
ELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQK
YLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRI
LLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR
RQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR
ENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
3D structure
PDB8cvt Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP D I167 G168 M170 G209 C210 G211 K212 T213 M214 I344 G372 A373 N376 I129 G130 M132 G171 C172 G173 K174 T175 M176 I306 G334 A335 N338
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001824 blastocyst development
GO:0006508 proteolysis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031597 cytosolic proteasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cvt, PDBe:8cvt, PDBj:8cvt
PDBsum8cvt
PubMed35858375
UniProtP43686|PRS6B_HUMAN 26S proteasome regulatory subunit 6B (Gene Name=PSMC4)

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