Structure of PDB 8ctm Chain D

Receptor sequence
>8ctmD (length=308) Species: 5661 (Leishmania donovani) [Search protein sequence]
PRKIILDCDPGIDDAVAIFLAHGNPEVELLAITTVVGNQTLEKVTRNARL
VADVAGIVGVPVAAGCTKPLVRGVRSQIHGETGMGNVSYPPEFKTKLDGR
HAVQLIIDLIMSHEPKTITLVPTGGLTNIAMAVRLEPRIVDRVKEVVLMG
GGYHTGNASPVAEFNVFVDPEAAHIVFNESWNVTMVGLDLTHQALATPAV
QKRVKEVGTKPAAFMLQILDFYTKVYEKNTYATVHDPCAVAYVIDPTVMT
TEQVPVDIELNGALTTGMTVADFRYPRPKHCHTQVAVKLDFDKFWCLVID
ALKRIGDP
3D structure
PDB8ctm Crystal structure of the nucleoside hydrolase from Leishmania donovani.
ChainD
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.1: purine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D D10 D15 T126 D241 D9 D14 T123 D236
Gene Ontology
Molecular Function
GO:0008477 purine nucleosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0045437 uridine nucleosidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006152 purine nucleoside catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ctm, PDBe:8ctm, PDBj:8ctm
PDBsum8ctm
PubMed
UniProtQ8WQX2

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