Structure of PDB 8co4 Chain D

Receptor sequence

>8co4D (length=379) Species: 3702 (Arabidopsis thaliana)

MATQGQVITCKAAVAYEPNKPLVIEDVQVAPPQAGEVRIKILYTALCHTD
AYTWSGKDPEGLFPCILGHEAAGIVESVGEGVTEVQAGDHVIPCYQAECR
ECKFCKSGKTNLCGKVRSATGVGIMMNDRKSRFSVNGKPIYHFMGTSTFS
QYTVVHDVSVAKIDPTAPLDKVCLLGCGVPTGLGAVWNTAKVEPGSNVAI
FGLGTVGLAVAEGAKTAGASRIIGIDIDSKKYETAKKFGVNEFVNPKDHD
KPIQEVIVDLTDGGVDYSFECIGNVSVMRAALECCHKGWGTSVIVGVAAS
GQEISTRPFQLVTGRVWKGTAFGGFKSRTQVPWLVEKYMNKEIKVDEYIT
HNLTLGEINKAFDLLHEGTCLRCVLDTSK

3D structure

• PDB: 8co4 Structural and biochemical characterization of Arabidopsis alcohol dehydrogenases reveals distinct functional properties but similar redox sensitivity.
• Chain: D
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.-
  1.1.1.1: alcohol dehydrogenase.
  1.1.1.284: S-(hydroxymethyl)glutathione dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	D	C99 C102 C105 C113	C99 C102 C105 C113
BS02	ZN	D	C47 H69 C177	C47 H69 C177

Gene Ontology

Molecular Function

• GO:0004022 alcohol dehydrogenase (NAD+) activity
• GO:0008270 zinc ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
• GO:0080007 S-nitrosoglutathione reductase (NADH) activity
• GO:0106321 S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
• GO:0106322 S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity

Biological Process

• GO:0044281 small molecule metabolic process
• GO:0046294 formaldehyde catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:8co4, PDBe:8co4, PDBj:8co4
• PDBsum: 8co4
• PubMed: 38308388
• UniProt: Q96533|ADHX_ARATH Alcohol dehydrogenase class-3 (Gene Name=ADH2)