Structure of PDB 8ch6 Chain D

Receptor sequence
>8ch6D (length=89) Species: 9606 (Homo sapiens) [Search protein sequence]
KHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYG
SYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNL
3D structure
PDB8ch6 Structural basis of catalytic activation in human splicing.
ChainD
Resolution5.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D K3 K25 Y36 K1 K23 Y34
BS02 ZN D C11 C85 C9 C83
BS03 ZN D C30 C33 C72 C75 C28 C31 C70 C73
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:0048863 stem cell differentiation
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome

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Cellular Component
External links
PDB RCSB:8ch6, PDBe:8ch6, PDBj:8ch6
PDBsum8ch6
PubMed37165190
UniProtQ7RTV0|PHF5A_HUMAN PHD finger-like domain-containing protein 5A (Gene Name=PHF5A)

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