Structure of PDB 8bla Chain D

Receptor sequence
>8blaD (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
RPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVL
TTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGK
SPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYA
EMKFYVVIRRR
3D structure
PDB8bla Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VTX D W178 M223 Y229 W148 M193 Y199
BS02 VTX D W85 R87 Y148 W55 R57 Y118
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:8bla, PDBe:8bla, PDBj:8bla
PDBsum8bla
PubMed38698207
UniProtP46098|5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (Gene Name=HTR3A)

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