Structure of PDB 8biq Chain D

Receptor sequence
>8biqD (length=561) Species: 399549 (Metallosphaera sedula DSM 5348) [Search protein sequence]
VQDFFRKFIEFQNSPNEKSLQEIVKLVGQLDLRRFNWVRDVFEDIHVKER
GSKTALIWRDINTGEEAKLSYHELSLMSNRVLSTLRKHGLKKGDVVYLMT
KVHPMHWAVFLAVIKGGFVMVPSATNLTVAEMKYRFSDLKPSAIISDSLR
ASVMEEALGSLKVEKFLIDGKRETWNSLEDESSNAEPEDTRGEDVIINYF
TSGTTGMPKRVIHTAVSYPVGSITTASIVGVRESDLHLNLSATGWAKFAW
SSFFSPLLVGATVVGINYEGKLDTRRYLGEVENLGVTSFCAPPTAWRQFI
TLDLDQFRFERLRSVVSAGEPLNPEVIKIWKDKFNLTIRDFYGQTETTAM
VGNFPFLKVKPGSMGKPHPLYDIRLLDDEGKEITKPYEVGHITVKLNPRP
IGLFLGYSDEKKNMESFREGYYYTGDKAYFDEEGYFYFVGRGDDVIKTSD
YRVGPFEVESALLEHPAVAEAAVVGVPDTVRWQLVKAYIVLKKGYMPSKE
LAEEIREKMKTLLSPYKVPRIIEFVDELPKTISGKIRRVELRKREEEKRK
KGEVGQNEYVF
3D structure
PDB8biq Crystal structure of acyl-COA synthetase from Metallosphaera sedula in complex with acetyl-AMP
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
6.2.1.17: propionate--CoA ligase.
6.2.1.2: medium-chain acyl-CoA ligase.
6.2.1.40: 4-hydroxybutyrate--CoA ligase (AMP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP D G328 E329 P330 D349 Y351 G352 Q353 T354 D435 F447 K456 G319 E320 P321 D340 Y342 G343 Q344 T345 D426 F438 K447
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0004321 fatty-acyl-CoA synthase activity
GO:0005524 ATP binding
GO:0015645 fatty acid ligase activity
GO:0016874 ligase activity
GO:0031956 medium-chain fatty acid-CoA ligase activity
GO:0050218 propionate-CoA ligase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8biq, PDBe:8biq, PDBj:8biq
PDBsum8biq
PubMed
UniProtA4YDT1|HBCL1_METS5 4-hydroxybutyrate--CoA ligase 1 (Gene Name=Msed_0406)

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