Structure of PDB 8b69 Chain D

Receptor sequence
>8b69D (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHK
3D structure
PDB8b69 Structural insights into the complex of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
ChainD
Resolution3.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D S17 T35 S18 T36
BS02 GNP D G13 V14 G15 K16 S17 A18 F28 D30 Y32 G60 N116 K117 D119 L120 G14 V15 G16 K17 S18 A19 F29 D31 Y33 G61 N116 K117 D119 L120
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b69, PDBe:8b69, PDBj:8b69
PDBsum8b69
PubMed37833074
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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