Structure of PDB 7zyw Chain D

Receptor sequence

>7zywD (length=414) Species: 9913 (Bos taurus)

REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYY
NEGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAK
GHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLIS
KIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCID
NEALYDICFRTLKLTPTYGDLNHLVSATMSGVTTCLRFPGADLRKLAVNM
VPFPRLHFFMPGFAPLLTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIF
RGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATF
IGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMND
LVSEYQQYQDATAD

3D structure

• PDB: 7zyw Structure of T2R-TTL-PM534 complex
• Chain: D
• Resolution: 2.45 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GDP	D	G10 Q11 C12 S140 G143 G144 T145 E183 N206 Y224 N228	G9 Q10 C11 S135 G138 G139 T140 E178 N201 Y218 N222
BS02	KG0	D	Q136 N167 F169 E200 Y202 V238 C241 L255 N258 M259 A316 I318 A354 T376 F377	Q131 N162 F164 E195 Y197 V232 C235 L246 N249 M250 A297 I299 A335 T349 F350

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0046872 metal ion binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process
• GO:0007399 nervous system development
• GO:1902669 positive regulation of axon guidance

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule
• GO:0015630 microtubule cytoskeleton

External links

• PDB: RCSB:7zyw, PDBe:7zyw, PDBj:7zyw
• PDBsum: 7zyw
• PubMed: 38294341
• UniProt: Q6B856|TBB2B_BOVIN Tubulin beta-2B chain (Gene Name=TUBB2B)