Structure of PDB 7zr1 Chain D

Receptor sequence
>7zr1D (length=780) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence]
SKIEKLSILGVRSFGPHHPETIAFNTPLTLIVGYNGSGKTTVIECLKYAT
TGELPPNSTRNGAFIHDPDLVGEKEVRAQVKLSFRSTIGESYVVTRNIQL
LVQRNNKRTQKTLEGSLLLRNNGERTVISTRVAELDKLVSEKLGVPPAIL
DAVIFCHQDDSLWPMSEPAALKKRFDEIFEAQKYTKVIENIRLLKKKKGD
ELKILKEREVQDKANKERAEKVDRLMAQLTREILEAREKCNELSKQMEEE
SAKIKDKYEQANSFLKIMNDLQTKTEKLEYKKDAIVELRSRIEELPDPDE
VLRNTLDEYEQTINRIVADRDHKAAQFHDLQAELKSARDQHTAKAAEQGK
HQSDKEKYERQLVARERMIREAAERHEIRGYNGDLDDRRIAIFNERIQKI
LNDKRRELERLQKEQKVAAERDAIAQTVSELNMINSEIQEYLDRGGPSSL
AANQRAIANLETQMANLEGEMRELTVQINKLNKEIDNSDAKKRNIADNLT
YRKNLREKDALEREIAELEARNAQEDYDRLIKEAHYLEAHRSKLNADRER
LMGMMSTKDEEFRRLNEEYELDLKDAKAKYKETHIKVETTKAAIEDLGRG
MAAVDHAIMQYHSKMMEQINRTIAELWQSTYQGTDIDTIQIRSDVESTTS
SDSGTRRNYNYRVSMVKGDTEMDMRGRCSAGQKVLASIIIRLALAESFCA
NCGLIALDEPTTNLDSDNIRSLAESLHGIIKARQAQGNLQLIVITHDEEF
LKYMQCSDFCDDFYRVKRDEKQNSVIVRES
3D structure
PDB7zr1 Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
ChainD
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS D R1206 C1207 R677 C678
BS02 MG D T41 Q159 T40 Q158
BS03 AGS D N36 G37 G39 K40 T41 T42 Q159 N35 G36 G38 K39 T40 T41 Q158
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043047 single-stranded telomeric DNA binding
GO:0046872 metal ion binding
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0007004 telomere maintenance via telomerase
GO:0032508 DNA duplex unwinding
GO:0070192 chromosome organization involved in meiotic cell cycle
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030870 Mre11 complex
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zr1, PDBe:7zr1, PDBj:7zr1
PDBsum7zr1
PubMed36577401
UniProtG0SHW7|RAD50_CHATD DNA repair protein RAD50 (Gene Name=RAD50)

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