Structure of PDB 7zlm Chain D

Receptor sequence
>7zlmD (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSD
YLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKKLKQFDSVVHLIDYYV
QMCKDVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLE
EYKFQV
3D structure
PDB7zlm Structure-based design of a phosphotyrosine-masked, cell-penetrant small molecule covalently targeting Cys111 on the E3 ligase SOCS2
ChainD
Resolution1.79 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JIH D V55 K59 R73 S75 S76 T83 T93 N94 L95 R96 I110 C111 V148 V26 K30 R44 S46 S47 T54 T64 N65 L66 R67 I81 C82 V106
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:7zlm, PDBe:7zlm, PDBj:7zlm
PDBsum7zlm
PubMed37816714
UniProtO14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (Gene Name=SOCS2)

[Back to BioLiP]