Structure of PDB 7z34 Chain D

Receptor sequence

>7z34D (length=273) Species: 559292 (Saccharomyces cerevisiae S288C)

KSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQNTPKYRLVVRFTNKDIIC
QIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGLLIARRTLQK
LGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRTTTGARVFGA
LKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFGGHVSQYMEELA
DDDEERFSELFKGYLADDIDADSLEDIYTSAHEAIRADPAFKPTEKKFTK
EQYAAESKKYRQTKLSKEERAAR

3D structure

• PDB: 7z34 Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
• Chain: D
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	A11 Y12 R15 F16 Q17 R23 T28 D29 Y31 Q32 R35 L36 Y49 L113 R140 P141 F142 K143 F145 I148 T153 P174	A4 Y5 R8 F9 Q10 R16 T21 D22 Y24 Q25 R28 L29 Y37 L101 R128 P129 F130 K131 F133 I136 T141 P162
BS02	rna	D	K8 F16 T18 F20 R21 R22 R24 E25 T28 R33 N57 K58 I69 T70 D72 V74 Y79 G91 T93 N94 W95 Q151 R152 T155 G156 A157 R158 P181 Y207 Y226 T256 Y265 E268 K270 Y272 R273 K276 L277 R285	K1 F9 T11 F13 R14 R15 R17 E18 T21 R26 N45 K46 I57 T58 D60 V62 Y67 G79 T81 N82 W83 Q139 R140 T143 G144 A145 R146 P169 Y195 Y214 T244 Y253 E256 K258 Y260 R261 K264 L265 R273

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7z34, PDBe:7z34, PDBj:7z34
• PDBsum: 7z34
• PubMed: 36097293
• UniProt: P26321|RL5_YEAST Large ribosomal subunit protein uL18 (Gene Name=RPL5)