Structure of PDB 7ytj Chain D

Receptor sequence
>7ytjD (length=601) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MAKFGEHLSKSLIRQYSYYYISYDDLKTELEDNLSKNNGQWTQELETDFL
ESLEIELDKVYTFCKVKHSEVFRRVKEVQEQVQHTVRLLDSNNPPTQLDF
EILEEELSDIIADVHDLAKFSRLNYTGFQKIIKKHDKKTGFILKPVFQVR
LDSKPFFKENYDELVVKISQLYDIARTSGRPFVRQTTKYWVHPDNITELK
LIILKHLPVLVFNTNKEFEREDSAITSIYFDNENLDLYYGRLRKDEGAEA
HALAWYGGMSTDTIFVERKTHREDWTGEKSVKARFALKERHVNDFLKGKY
TVDQVFAKMRKEGKKPMNEIENLEALASEIQYVMLKKKLRPVVRSFYNRT
AFQLPGDARVRISLDTELTMVREDNFDGVDRTHKNWRRTDIGVDWPFKQL
DDKDICRFPYAVLNVKLQTQLGQEPPEWVRELVGSHLVEPVPKFSKFIHG
VATLLNDKVDSIPFWLPQMDVDIRKPPLFDTQIRAPPGKTICVPVRVEPK
VYFATERTYLSWLSISILLGGVSTTLLTYGSPTAMIGSIGFFITSLAVLI
RTVMVYAKRVVNIRLKRAVDYEDKIGPGMVSVFLILSILFSFFCNLVAKL
E
3D structure
PDB7ytj The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.1: ATP-polyphosphate phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP D F4 Y23 K27 K130 K133 K137 F4 Y23 K27 K130 K133 K137
BS02 IHP D T199 K201 K282 S293 K295 R362 K429 T186 K188 K269 S280 K282 R349 K416
BS03 IHP D K301 R303 K321 K288 R290 K308
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008976 polyphosphate kinase activity
GO:0016740 transferase activity
Biological Process
GO:0006797 polyphosphate metabolic process
GO:0006799 polyphosphate biosynthetic process
GO:0007034 vacuolar transport
GO:0016237 microautophagy
GO:0042144 vacuole fusion, non-autophagic
GO:0061736 engulfment of target by autophagosome
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0000421 autophagosome membrane
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0033254 vacuolar transporter chaperone complex
GO:0071944 cell periphery

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ytj, PDBe:7ytj, PDBj:7ytj
PDBsum7ytj
PubMed36759618
UniProtP47075|VTC4_YEAST Vacuolar transporter chaperone complex subunit 4 (Gene Name=VTC4)

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