Structure of PDB 7yg5 Chain D

Receptor sequence
>7yg5D (length=955) Species: 9606 (Homo sapiens) [Search protein sequence]
FPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGS
TIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDN
SRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSV
SEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNIT
AKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKY
NKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEY
LDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENK
TNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPN
LQPKPIGVGIPTQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTL
VKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQ
ARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKT
PNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGIT
RVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESG
IMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRMDCVILDDGG
FLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPG
AASKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIM
VESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLED
YTDCG
3D structure
PDB7yg5 Structural insights into allosteric effects of antiepileptic drug topiramate on CaV2.3 channel.
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D S261 S263 T331 S235 S237 T305
External links
PDB RCSB:7yg5, PDBe:7yg5, PDBj:7yg5
PDBsum7yg5
PubMed38901222
UniProtP54289|CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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