Structure of PDB 7y8l Chain D

Receptor sequence
>7y8lD (length=285) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence]
PAPLTLIGLGPMGQAMGNALLDRGHGLTVWNRTASRADALVERGAVRAPD
VAAAVAANELVVLSLTDYDAMYALLGPAADALAGKVVVNLSSDTPEKTRA
GARWIAEHGGTLIAGGVTCPPSGIGSPESSAFYSGPSAAFERHRETLRTL
TRTDYRGEDPGLAALWYQIGMVMWWNAMLGYLQAVALADANGLKAADILP
HASDTVAGLPFFLRFYADRIDTGHHGGDADRLAMGTASVEHILHTMADSG
VDTALPEAVVAFFRRGEAAGYAENSFSSMVELLKK
3D structure
PDB7y8l Engineered Imine Reductase for Larotrectinib Intermediate Manufacture
ChainD
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D R234 M237 R231 M234
BS02 4IS D F215 D233 M237 F212 D230 M234
BS03 4IS D C122 P123 M174 W177 C119 P120 M171 W174
BS04 NDP D L12 P14 M15 N34 R35 T36 S67 L68 T69 A73 L77 S95 V120 C122 P124 Y170 L9 P11 M12 N31 R32 T33 S64 L65 T66 A70 L74 S92 V117 C119 P121 Y167
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
Biological Process
GO:0016054 organic acid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7y8l, PDBe:7y8l, PDBj:7y8l
PDBsum7y8l
PubMed
UniProtE2PUR9

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