Structure of PDB 7y0f Chain D

Receptor sequence
>7y0fD (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNP
WHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPL
TFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLI
ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWL
IGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
3D structure
PDB7y0f Crystal structure of TMPRSS2 in complex with UK-371804
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.122: transmembrane protease serine 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I9V D D435 S436 C437 Q438 S441 W461 G462 G464 C465 D180 S181 C182 Q183 S186 W206 G207 G209 C210
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7y0f, PDBe:7y0f, PDBj:7y0f
PDBsum7y0f
PubMed37990007
UniProtO15393|TMPS2_HUMAN Transmembrane protease serine 2 (Gene Name=TMPRSS2)

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