Structure of PDB 7y0b Chain D

Receptor sequence
>7y0bD (length=385) Species: 9606 (Homo sapiens) [Search protein sequence]
IYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGL
GLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPI
LKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSW
VLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKK
EDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIAS
QALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLL
TWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMP
AERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
3D structure
PDB7y0b Crystal structure of human short-chain acyl-coA dehydrogenase
ChainD
Resolution2.076 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.8.1: short-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD D R297 F300 L307 Q365 I366 G369 R270 F273 L280 Q338 I339 G342
BS02 FAD D F152 L154 S155 G160 S161 W185 T187 I387 T394 E396 L400 F125 L127 S128 G133 S134 W158 T160 I360 T367 E369 L373
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0046359 butyrate catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005813 centrosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7y0b, PDBe:7y0b, PDBj:7y0b
PDBsum7y0b
PubMed
UniProtP16219|ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADS)

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