Structure of PDB 7xyk Chain D

Receptor sequence
>7xykD (length=288) Species: 654913 (Shrimp white spot syndrome virus (isolate Tongan)) [Search protein sequence]
MEGEHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLT
TKKIFWRGVVEELLWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYD
RAEGDLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDDR
RMIMTAWNPMDLHLMALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVPF
NIASYSLLTHLMASMVGLKPGEFILTLGDAHIYNTHIEVLKKQLCRVPRP
FPKLRILMAPEKIEDFTIDMFYLEGYQPHSGNLQMKMA
3D structure
PDB7xyk Structure of WSSV thymidylate synthase in complex with dUMP and raltitrexed
ChainD
Resolution1.433 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP D R150 R151 R150 R151
BS02 UMP D R24 C170 R190 S191 D193 N201 H231 Y233 R24 C170 R190 S191 D193 N201 H231 Y233
BS03 D16 D F55 I83 W84 D193 L196 G197 F200 M285 M287 F55 I83 W84 D193 L196 G197 F200 M285 M287
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xyk, PDBe:7xyk, PDBj:7xyk
PDBsum7xyk
PubMed
UniProtQ77J90

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