Structure of PDB 7xqa Chain D

Receptor sequence

>7xqaD (length=479) Species: 285500 (Streptomyces luteocolor) [Search protein sequence]

VIVVGNGVLGLSVGVEIARTRPDVRVTLLGKPARQYGATPAAGAMLGAFG
EVTAHALASEHGRKKHALAVQAQRLWPEWIESLEATGTAADGRIKTADDT
VVLLNTVGHSALDDANFAAVLTALKEANAPHEEIAVESVDWIDPDPNSRP
LRALHIEGEGSVDSGILLAALERSFLQAGGRLHPVDATEIRASHGRVEGV
VTDDGDFLPAGHVVVAAGARSQRLVAALPGLAHRIPRIYDGVGVSALVDT
WDGSGPATVLRTSNRAFACGLHLVPRAGGSVYIGATNAVCLEPRGAASIE
ETVFLFNCATHQLHRGLNGSELRKVQVGSRPAPIDGFPLIGGTSVEGLWM
LSGTYRDGLHMSPLLARHVVSLMDGGTGVDGLREFRPERDLISAWSREEI
LDDVVRHTMATGYEFPWRLPLEWPHMMETFLQGPFAELADRLSDTYTPPA
DLMTAIMFSEREQQDELIAYYADVHREWH

3D structure

PDB

7xqa N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry

Chain

Resolution

1.93 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	D	V16 G17 N18 G19 V20 L21 G42 R46 Q47 G49 A50 T51 A53 A54 M57 D198 A199 A229 G230 R232 G340 R342 T366 Y367 R368 D369 G370 L371 H372	V4 G5 N6 G7 V8 L9 G30 R34 Q35 G37 A38 T39 A41 A42 M45 D186 A187 A217 G218 R220 G328 R330 T354 Y355 R356 D357 G358 L359 H360
BS02	GLY	D	H284 R342 R368	H272 R330 R356

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7xqa, PDBe:7xqa, PDBj:7xqa
PDBsum	7xqa
PubMed	37137912
UniProt	A0A125SZC1

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