Structure of PDB 7xlq Chain D

Receptor sequence
>7xlqD (length=955) Species: 9606 (Homo sapiens) [Search protein sequence]
FPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGS
TIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDN
SRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSV
SEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNIT
AKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKY
NKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEY
LDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENK
TNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPN
LQPKPIGVGIPTQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTL
VKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQ
ARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKT
PNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGIT
RVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESG
IMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRMDCVILDDGG
FLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPG
AASKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIM
VESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLED
YTDCG
3D structure
PDB7xlq Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D S261 S263 S235 S237
Gene Ontology
Molecular Function
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0046872 metal ion binding
GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential
Biological Process
GO:0006816 calcium ion transport
GO:0051924 regulation of calcium ion transport
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060402 calcium ion transport into cytosol
GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0070588 calcium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098703 calcium ion import across plasma membrane
GO:0098903 regulation of membrane repolarization during action potential
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1904646 cellular response to amyloid-beta
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016529 sarcoplasmic reticulum
GO:0030315 T-tubule
GO:0034702 monoatomic ion channel complex
GO:0048787 presynaptic active zone membrane
GO:0070062 extracellular exosome
GO:0098982 GABA-ergic synapse
GO:0098992 neuronal dense core vesicle
GO:1990454 L-type voltage-gated calcium channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xlq, PDBe:7xlq, PDBj:7xlq
PDBsum7xlq
PubMed36720859
UniProtP54289|CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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