Structure of PDB 7xjb Chain D

Receptor sequence
>7xjbD (length=213) Species: 10116 (Rattus norvegicus) [Search protein sequence]
DTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDA
VIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQM
LNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTL
LLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMK
VVDGLEKAIYQGP
3D structure
PDB7xjb Structural and Computational Analyses of the Unique Interactions of Opicapone in the Binding Pocket of Catechol O -Methyltransferase: A Crystallographic Study and Fragment Molecular Orbital Analyses.
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.6: catechol O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM D M40 N41 V42 G66 Y68 Y71 S72 E90 M91 Y95 A118 S119 D141 H142 W143 M38 N39 V40 G64 Y66 Y69 S70 E88 M89 Y93 A116 S117 D139 H140 W141
BS02 DNI D W38 M40 K144 N170 P174 L198 E199 W36 M38 K142 N168 P172 L196 E197
BS03 MG D D141 D169 N170 D139 D167 N168
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
Biological Process
GO:0006584 catecholamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7xjb, PDBe:7xjb, PDBj:7xjb
PDBsum7xjb
PubMed37436881
UniProtP22734|COMT_RAT Catechol O-methyltransferase (Gene Name=Comt)

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