Structure of PDB 7xj0 Chain D

Receptor sequence
>7xj0D (length=606) Species: 9606 (Homo sapiens) [Search protein sequence]
RLKKRIFAAVSEGCVEELVELLVELQELCRRRVPDFLMHKLTASDTGKTC
LMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNI
AIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAAC
TNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMY
DMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLR
SLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLT
LEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPRGWLQLLG
RMFVLIWAMCISVKEGIAIFLLSDAWFHFVFFIQAVLVILSVFLYLFAYK
EYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYI
VFLLGFGVALASLIEKCPKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNS
KYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRAR
TILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSF
LNEDPG
3D structure
PDB7xj0 Structural basis of TRPV3 inhibition by an antagonist.
ChainD
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6OU D Y594 S626 F633 Y449 S478 F485
BS02 EQK D A556 W559 A560 A411 W414 A415
BS03 EQK D V596 F597 G600 F601 F656 T660 L664 V451 F452 G455 F456 F508 T512 L516
BS04 6OU D I652 L655 I504 L507
BS05 6OU D K438 F441 F442 F445 M562 L563 F569 K317 F320 F321 F324 M417 L418 F424
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006811 monoatomic ion transport
GO:0008218 bioluminescence
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7xj0, PDBe:7xj0, PDBj:7xj0
PDBsum7xj0
PubMed36302896
UniProtQ8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (Gene Name=TRPV3)

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