Structure of PDB 7xd8 Chain D

Receptor sequence

>7xd8D (length=621) Species: 11060 (dengue virus type 2)

SETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSAS
SMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKE
GTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENK
WKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKA
KGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYI
LRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAI
FKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQ
LIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVVK
PLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIM
KDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFH
RRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWI
QENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAIN
QVRSLIGNEEYTDYMPSMKRF

3D structure

• PDB: 7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Chain: D
• Resolution: 2.85 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	K402 R404 A408 M455 K457 I474 Y476 R482 N493 G509 G602 V604 W803 M804 V812 R815	K134 R136 A140 M187 K189 I206 Y208 R214 N225 G241 G334 V336 W535 M536 V544 R547
BS02	rna	D	S405 S661 G662 D663 C709 S710 L754 Y758 M761 T790 S791 R792	S137 S393 G394 D395 C441 S442 L486 Y490 M493 T522 S523 R524
BS03	ZN	D	H712 H714 C728 C847	H444 H446 C460 C579
BS04	ZN	D	E438 H442 C447 C450	E170 H174 C179 C182

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
• PDBsum: 7xd8
• PubMed: 36577062
• UniProt: Q91H74