Structure of PDB 7wx3 Chain D

Receptor sequence
>7wx3D (length=258) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
PTFTERSQLKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLE
GREVMMVTSGAVAFGKQKLAQELLMSLSMRETLNLEPRAAAAVGQSGLMS
LYDAMFAQYGVKIAQVLVTKPDFYNEETRNNLFCTLSELISLNIVPIINT
NDAVSPPMFIPIKDNDSLSAMLAAEVQADLLILMSDVDGIYNKPPWEDGA
KLMHTYTSDDSNSIMDSKVKAATWALDRGVSVVICNGMQEKAIKTIIGGR
KVGTFFTE
3D structure
PDB7wx3 Structural basis of dynamic P5CS filaments.
ChainD
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.2.1.41: glutamate-5-semialdehyde dehydrogenase.
2.7.2.11: glutamate 5-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D E116 M119 S120 L121 S122 M123 R124 E72 M75 S76 L77 S78 M79 R80
BS02 RGP D S103 A105 N204 T205 D207 M213 N233 S59 A61 N149 T150 D152 M158 N165
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004349 glutamate 5-kinase activity
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0016310 phosphorylation
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wx3, PDBe:7wx3, PDBj:7wx3
PDBsum7wx3
PubMed35286254
UniProtQ9VNW6

[Back to BioLiP]