Structure of PDB 7wte Chain D

Receptor sequence
>7wteD (length=1147) Species: 9606 (Homo sapiens) [Search protein sequence]
LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKAD
EAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQAC
QDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAH
EFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNG
ALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAA
HLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQV
EHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTE
DPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIA
HGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFI
DENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPA
VPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATR
VRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELR
ELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLN
YLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELV
RAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVA
AMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERV
FDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSM
GLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEA
EAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGAS
LPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLD
SLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELN
GQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKV
AKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE
3D structure
PDB7wte Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.1: pyruvate carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO D F53 R54 T57 R77 K79 A80 F22 R23 T26 R46 K48 A49
BS02 ACO D R451 R453 Q494 N495 R496 A497 K1056 L1058 R420 R422 Q463 N464 R465 A466 K1025 L1027
BS03 ATP D G199 M204 F238 I239 Q268 H271 G168 M173 F207 I208 Q237 H240
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004736 pyruvate carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
GO:0006629 lipid metabolic process
GO:0006734 NADH metabolic process
GO:0006739 NADP metabolic process
GO:0010629 negative regulation of gene expression
GO:0019074 viral RNA genome packaging
GO:0019076 viral release from host cell
GO:0044794 positive regulation by host of viral process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wte, PDBe:7wte, PDBj:7wte
PDBsum7wte
PubMed36283412
UniProtP11498|PYC_HUMAN Pyruvate carboxylase, mitochondrial (Gene Name=PC)

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