Structure of PDB 7wtd Chain D

Receptor sequence
>7wtdD (length=1145) Species: 9606 (Homo sapiens) [Search protein sequence]
YKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEA
YLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQD
AGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEF
SNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGAL
FVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHL
DPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEH
TVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDP
ARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHG
KDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDE
NPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVP
IGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVR
THDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELREL
IPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYL
PNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRA
GTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAM
LACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFD
YSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGL
GSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEA
QAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLP
PLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSL
NTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQ
LRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAK
GQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE
3D structure
PDB7wtd Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
ChainD
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.1: pyruvate carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA D T57 Q78 A80 D81 E82 T24 Q45 A47 D48 E49
BS02 COA D R398 R445 R451 R453 Q494 R496 K1056 R365 R412 R418 R420 Q461 R463 K1023
BS03 ATP D G199 M204 F238 I239 Q268 H271 G166 M171 F205 I206 Q235 H238
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004736 pyruvate carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
GO:0006629 lipid metabolic process
GO:0006734 NADH metabolic process
GO:0006739 NADP metabolic process
GO:0010629 negative regulation of gene expression
GO:0019074 viral RNA genome packaging
GO:0019076 viral release from host cell
GO:0044794 positive regulation by host of viral process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wtd, PDBe:7wtd, PDBj:7wtd
PDBsum7wtd
PubMed36283412
UniProtP11498|PYC_HUMAN Pyruvate carboxylase, mitochondrial (Gene Name=PC)

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