Structure of PDB 7wiy Chain D

Receptor sequence
>7wiyD (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
VPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG
YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYC
GYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDED
VQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAF
DPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPY
TQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
3D structure
PDB7wiy Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2.
ChainD
Resolution3.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.16.4: tryptophan 5-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE D H318 H323 E363 H168 H173 E213
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0046872 metal ion binding
Biological Process
GO:0009072 aromatic amino acid metabolic process
GO:0042427 serotonin biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wiy, PDBe:7wiy, PDBj:7wiy
PDBsum7wiy
PubMed36046836
UniProtQ8IWU9|TPH2_HUMAN Tryptophan 5-hydroxylase 2 (Gene Name=TPH2)

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