Structure of PDB 7wdb Chain D

Receptor sequence
>7wdbD (length=665) Species: 9606 (Homo sapiens) [Search protein sequence]
RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECV
SSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSK
VENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDLAKLKVAI
KYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPML
SIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHVQGPPPT
VVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATIS
LKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANS
HLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPN
NCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVG
ATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF
DEGGTLPPPFNIISLIQNQHYQEVIRNLVKRYVAAMIRNSKTTEENFKEL
KQDISSFRYEVLDLL
3D structure
PDB7wdb Structural identification of riluzole-binding site on human TRPC5.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7OC D F599 A602 T603 F548 A551 T552
BS02 Y01 D Y316 F364 L496 F497 N500 Y272 F320 L445 F446 N449
BS03 ZN D H172 C176 C178 C181 H140 C144 C146 C149
BS04 CA D E418 N436 D439 E367 N385 D388
BS05 657 D Y374 D439 R492 L496 Y330 D388 R441 L445
BS06 7OC D Y524 Q573 F576 Y473 Q522 F525
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wdb, PDBe:7wdb, PDBj:7wdb
PDBsum7wdb
PubMed35821012
UniProtQ9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)

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