Structure of PDB 7w3b Chain D

Receptor sequence
>7w3bD (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]
DLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLV
IGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNA
LVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHF
ELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQK
YLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRI
LLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR
RQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR
ENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
3D structure
PDB7w3b USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainD
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D K238 Y239 K200 Y201
BS02 ATP D R323 R326 R285 R288
BS03 ATP D I167 P208 G209 C210 G211 K212 T213 M214 I344 I348 G372 A373 N376 I129 P170 G171 C172 G173 K174 T175 M176 I306 I310 G334 A335 N338
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001824 blastocyst development
GO:0006508 proteolysis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031597 cytosolic proteasome complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7w3b, PDBe:7w3b, PDBj:7w3b
PDBsum7w3b
PubMed35477760
UniProtP43686|PRS6B_HUMAN 26S proteasome regulatory subunit 6B (Gene Name=PSMC4)

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