Structure of PDB 7w1y Chain D

Receptor sequence
>7w1yD (length=705) Species: 9606 (Homo sapiens) [Search protein sequence]
SGFDDPGIFYSDSFGGGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRD
ELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVA
DEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIA
ASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKC
PLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKV
VPGNRVTIMGIYSIKKFGLTTSRVGVGIRSSYIRVLGIQVDTAVSPQEEE
EFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLT
RRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIA
KAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIV
KDEHNEERDVMLAKHVITLHVSALVEGEIDLAKLKKFIAYCRVKCGPRLS
AEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSK
MKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRI
EKQLKRRFAIGSQVSEHSIIKDFTPEHAIHKVLQLMLRRGEIQHRMQRKV
LYRLK
3D structure
PDB7w1y The human pre-replication complex is an open complex.
ChainD
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D R195 K206 L209 S423 R188 K199 L202 S403
BS02 ATP D R371 V610 R611 E614 R351 V585 R586 E589
BS03 ZN D C172 C175 C197 C207 C165 C168 C190 C200
BS04 ADP D I343 F344 P383 T385 A386 K387 S388 Q389 H535 I323 F324 P363 T365 A366 K367 S368 Q369 H515
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071162 CMG complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w1y, PDBe:7w1y, PDBj:7w1y
PDBsum7w1y
PubMed36608662
UniProtP33992|MCM5_HUMAN DNA replication licensing factor MCM5 (Gene Name=MCM5)

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