Structure of PDB 7vxx Chain D

Receptor sequence
>7vxxD (length=150) Species: 64320 (Zika virus) [Search protein sequence]
VKKGETTDGVYRVMTRTQVGVGVMQEGVFHTMWHVTKGAALRSRLDPYWG
DVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIFKTKD
GDIGAVALDYPAGTSGSPILDKSGRVIGLYGNGVVIKNGSYVSAITQGKR
3D structure
PDB7vxx Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease.
ChainD
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PBZ D D129 Y130 A132 Y161 D109 Y110 A112 Y141
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7vxx, PDBe:7vxx, PDBj:7vxx
PDBsum7vxx
PubMed36049322
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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