Structure of PDB 7vpz Chain D

Receptor sequence
>7vpzD (length=1259) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
FDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTR
DWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWY
FKGVPSRLGYLLDLAPKDLEKVIYFAAYMITFVDEERRTRDLPSLEAHVS
VERQQIEQRRDSDLEARAKKLETDLAELEAEGAKADVRRKVREGAEREMK
QLRDRAQREIDRLDEVWNRFKNLKVQDLEGDELLYRELRDRFGTYFDGSM
GAAALQKRLESFDLDEEAERLREIIRTGKGQKKTRALKRLKVVSAFLQTS
NSPKGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKR
LLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDML
KGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFV
MKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHR
LGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEAR
ILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDSEGRSPKGEGRAFGS
SAEAIMAFDAGDLTLQAKIDIRFPVGTIPPRGFEPPAREEGEPEWQQGDT
FTLKTTLGRALFNELLPEDYPFVDYEVGKKQLSEIVNDLAERYPKVIVAA
TLDNLKAAGFFWATRSGVTVAISDIVVPDAKKEIVKGYEGQDEKVQKQYE
RGLITKEERTQELIAIWTKATNEVAEAMNDNFPKTNPVSMMVNSGARGNM
MQMRQIAGMRGLVSNAKNETIPRPIKASFREGLSVLEYFISTHGARKGLA
DTALRTADSGYLTRRLVDVSQDVIIREEDCGTERGLKLPIATRDADGTLR
KAEDVETSVYARMLAEDVVIDGKVIAPANVDLGDVLIDALVAHGVEEVKT
RSILTCESQVGTCAMCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTM
RTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEASGRVRIEETEKT
KKIVVTPDDGSDETAFPISKRARLLVGEGDHVEVGQKLTVGATNPHDVLR
ILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDA
ELLPGELVERTKFETENRRVVQEGGHPASGRPQLMGITKASLATESWLSA
ASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVE
PTEEAKAAM
3D structure
PDB7vpz Structural basis of Streptomyces transcription activation by zinc uptake regulator.
ChainD
Resolution4.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D Y36 P111 Y116 R291 K294 R1033 Y30 P105 Y110 R285 K288 R1027
BS02 dna D Q287 K409 R421 R427 P502 A863 Q1210 E1211 Q281 K403 R415 R421 P496 A857 Q1204 E1205
BS03 rna D R500 D539 R494 D533
BS04 MG D D535 D539 D529 D533
BS05 ZN D C60 C62 C54 C56
BS06 ZN D C886 C962 C972 C880 C956 C966
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vpz, PDBe:7vpz, PDBj:7vpz
PDBsum7vpz
PubMed35871291
UniProtQ8CJT1|RPOC_STRCO DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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