Structure of PDB 7uvr Chain D

Receptor sequence
>7uvrD (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPIVVEERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNK
KPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAG
TPGMRHSLPNSRIMIHQPSAIQAEEIMKLKKQLYNIYAKHTKQSLQVIES
AMERDRYMSPMEAQEFGILDKVLVHPP
3D structure
PDB7uvr Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
ChainD
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PJF D L79 E82 H116 Y118 W146 V148 L170 L17 E20 H54 Y56 W84 V86 L108
BS02 PJF D I100 L104 F105 S108 T135 Y138 I38 L42 F43 S46 T73 Y76
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7uvr, PDBe:7uvr, PDBj:7uvr
PDBsum7uvr
PubMed36586405
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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