Structure of PDB 7uva Chain D

Receptor sequence
>7uvaD (length=329) Species: 10090 (Mus musculus) [Search protein sequence]
RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
3D structure
PDB7uva Structural basis of paralog-specific KDM2A/B nucleosome recognition.
ChainD
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D D109 I144 S145 N186 I188 M191 Y199 K323 F324 R325 D74 I109 S110 N151 I153 M156 Y164 K288 F289 R290
BS02 FE D H212 D214 H284 H177 D179 H249
BS03 OH0 D I144 Y199 L201 T209 H212 Y222 K229 H284 V286 N298 I109 Y164 L166 T174 H177 Y187 K194 H249 V251 N263
External links
PDB RCSB:7uva, PDBe:7uva, PDBj:7uva
PDBsum7uva
PubMed36797403
UniProtP59997|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)

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