Structure of PDB 7uoe Chain D

Receptor sequence
>7uoeD (length=186) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
FSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAM
QRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNN
IINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWE
IQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA
3D structure
PDB7uoe Structural basis for substrate selection by the SARS-CoV-2 replicase.
ChainD
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D K36 R51 A54 K31 R46 A49
BS02 rna D K40 V44 K61 K35 V39 K56
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008242 omega peptidase activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:7uoe, PDBe:7uoe, PDBj:7uoe
PDBsum7uoe
PubMed36725929
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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