Structure of PDB 7umy Chain D

Receptor sequence
>7umyD (length=258) Species: 575584 (Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841) [Search protein sequence]
GLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEF
AEQFGSKLVFPCDVADAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDG
DFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSER
VMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGIK
SFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGF
NTVGMSQS
3D structure
PDB7umy An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections
ChainD
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D G15 A17 S21 I22 P42 D66 V67 S93 I94 L147 T148 Y149 K166 A192 G193 P194 I195 T197 G12 A14 S18 I19 P39 D63 V64 S89 I90 L143 T144 Y145 K162 A188 G189 P190 I191 T193
BS02 NUC D F96 A97 L102 N158 Y159 A199 S201 I203 F92 A93 L98 N154 Y155 A195 S197 I199
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7umy, PDBe:7umy, PDBj:7umy
PDBsum7umy
PubMed36188352
UniProtD0CAD5

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