Structure of PDB 7uhy Chain D

Receptor sequence
>7uhyD (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
AYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMAAGKVIIQDIACLLPVH
KSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGP
KSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRDP
RERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFV
SCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSN
FCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF
3D structure
PDB7uhy Structure of the nutrient-sensing hub GATOR2.
ChainD
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D G527 D531 A532 I534 P535 F536 G3 D7 A8 I10 P11 F12
BS02 ZN D C902 C905 C914 C917 C216 C219 C228 C231
BS03 ZN D C924 H946 H949 C238 H260 H263
BS04 ZN D C938 C941 C966 C252 C255 C280
BS05 ZN D C941 H943 C960 C964 C255 H257 C274 C278
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0035591 signaling adaptor activity
GO:0046872 metal ion binding
Biological Process
GO:0031669 cellular response to nutrient levels
GO:0034198 cellular response to amino acid starvation
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0035859 Seh1-associated complex
GO:0043231 intracellular membrane-bounded organelle
GO:0061700 GATOR2 complex

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Cellular Component
External links
PDB RCSB:7uhy, PDBe:7uhy, PDBj:7uhy
PDBsum7uhy
PubMed35831510
UniProtQ6PJI9|WDR59_HUMAN GATOR2 complex protein WDR59 (Gene Name=WDR59)

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