Structure of PDB 7uaf Chain D

Receptor sequence

>7uafD (length=529) Species: 9606 (Homo sapiens)

NGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEG
ESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYH
EQSRRDDYVNIWWDQILSGYQHNFDTYDDSLITPYDYESLMHYQPFSFNK
NASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTF
EKANICGMIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSS
GSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNV
RKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYL
DDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTL
YPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRM
SSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFI
SHQMLKRRSFLKNDDLIIFVDFEDITHLS

3D structure

• PDB: 7uaf Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
• Chain: D
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.18: meprin A.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FUC	D	T351 G352 H386 N414 T416	T280 G281 H315 N343 T345
BS02	M6X	D	C128 Q145 G146 C147 I152 E156 L211 Q241 R242	C63 Q80 G81 C82 I87 E91 L140 Q170 R171
BS03	CA	D	G282 D285 T287 D288	G211 D214 T216 D217
BS04	ZN	D	H155 H159 H165	H90 H94 H100
BS05	CA	D	T270 E272 D301 T303 Y313 D422	T199 E201 D230 T232 Y242 D351

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7uaf, PDBe:7uaf, PDBj:7uaf
• PDBsum: 7uaf
• PubMed: 36261433
• UniProt: Q16819|MEP1A_HUMAN Meprin A subunit alpha (Gene Name=MEP1A)