Structure of PDB 7u4e Chain D

Receptor sequence
>7u4eD (length=388) Species: 1086849 (Influenza A virus (A/Bilthoven/17938/1969(H3N2))) [Search protein sequence]
VEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQ
FALGQGTTLDNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSS
SCHDGKAWLHVCVTGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECV
CINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSCY
PRYPDVRCICRDNWKGSNRPIVDINMKDYSIDSSYVCSGLVGDTPRNDDR
SSKSNCRNPNNERGNHGVKGWAFDNGNDVWMGRTISKDLRSGYETFKVIG
GWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINRCFYVELIRGRE
QETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
3D structure
PDB7u4e Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase.
ChainD
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA D Q391 I392 R394 Q310 I311 R313
BS02 MAN D Q391 R394 Q310 R313
BS03 MAN D D330 R331 K389 D249 R250 K308
BS04 CA D D293 G297 D324 G345 H347 D212 G216 D243 G264 H266
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0033644 host cell membrane
GO:0044423 virion component
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u4e, PDBe:7u4e, PDBj:7u4e
PDBsum7u4e
PubMed36307418
UniProtH9XI12

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