Structure of PDB 7ttr Chain D

Receptor sequence
>7ttrD (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
RKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLV
FLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGS
PPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRL
TDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMITISKNFKEN
VIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQ
RHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLL
PGGCTLRITVEDSDKQLLKSPELPSPQAEKRLPK
3D structure
PDB7ttr Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.
ChainD
Resolution2.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide D G429 V431 G103 V105
BS02 AGS D I348 S383 G384 I385 G386 K387 T388 E455 N496 F571 L579 R620 I22 S57 G58 I59 G60 K61 T62 E129 N170 F228 L236 R277
BS03 MG D T388 E455 T62 E129
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:7ttr, PDBe:7ttr, PDBj:7ttr
PDBsum7ttr
PubMed36170828
UniProtQ9H078|CLPB_HUMAN Mitochondrial disaggregase (Gene Name=CLPB)

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