Structure of PDB 7tsw Chain D

Receptor sequence
>7tswD (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
PAITLESPDIKYPLRLIDREIISHDTRRFRFALPSPQHILGLPVGQHIYL
SARIDGNLVVRPYTPISSDDDKGFVDLVIKVYFKDDHPKFPAGGKMSQYL
ESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGG
TGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNKHSA
RFKLWYTLDRAPEAWDYGQGFVNEEMIRDHLPPPEEEPLVLMCGPPPMIQ
YACLPNLDHVGHPTERCFVF
3D structure
PDB7tsw Structure Of wild-type Human NADH-Cytochrome B5 Reductase and mutants
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.2.2: cytochrome-b5 reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD D R92 P93 Y94 T95 V109 Y113 H118 F121 G124 G125 K126 M127 S128 T182 T185 R61 P62 Y63 T64 V78 Y82 H87 F90 G93 G94 K95 M96 S97 T151 T154
Gene Ontology
Molecular Function
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005515 protein binding
GO:0016208 AMP binding
GO:0016491 oxidoreductase activity
GO:0043531 ADP binding
GO:0050421 nitrite reductase (NO-forming) activity
GO:0050660 flavin adenine dinucleotide binding
GO:0051287 NAD binding
GO:0071949 FAD binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006809 nitric oxide biosynthetic process
GO:0008015 blood circulation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0005833 hemoglobin complex
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0035578 azurophil granule lumen
GO:1903958 nitric-oxide synthase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tsw, PDBe:7tsw, PDBj:7tsw
PDBsum7tsw
PubMed
UniProtP00387|NB5R3_HUMAN NADH-cytochrome b5 reductase 3 (Gene Name=CYB5R3)

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