Structure of PDB 7tji Chain D

Receptor sequence
>7tjiD (length=434) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DPGFGSLQRRLLQQLYGTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKES
HSVILVGPRQSYKTYLLDYELSLLQQSYKEQFITIRLNGFIHSEQTAING
IATQLEQQLQKIHTISSGSLTEVFEKILLLLDSITKITVVFIFDEIDTFA
GPVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVI
YMPQIQNLDDMVDAVRNLLTVRSEISPWVSQWNETLEKELSDPRSNLNRH
IRMNFETFRSLPTLKNSIIPLVATSKNFGSLCTAIKSCSFLDIYNKNQLS
NNLTGRLQSLSDLELAILISAARVALRAKDGSFNFNLAYAEYEKMIKAIN
SRIKLWLKKDVKNVWENLVQLDFFTEKSAVGLRDNATAAFYASNYQFQGT
MIPFDLRSYQMQIILQELRRIIPKSNMYYSWTQL
3D structure
PDB7tji A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D R478 Y486 Y490 Q493 R383 Y391 Y395 Q398
BS02 ATP D H240 R267 H167 R194
BS03 ATP D R104 Q105 S106 Y107 K108 T109 Y110 K338 R59 Q60 S61 Y62 K63 T64 Y65 K265
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tji, PDBe:7tji, PDBj:7tji
PDBsum7tji
PubMed35217664
UniProtP54791|ORC4_YEAST Origin recognition complex subunit 4 (Gene Name=ORC4)

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