Structure of PDB 7tjh Chain D

Receptor sequence
>7tjhD (length=434) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DPGFGSLQRRLLQQLYGTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKES
HSVILVGPRQSYKTYLLDYELSLLQQSYKEQFITIRLNGFIHSEQTAING
IATQLEQQLQKIHTISSGSLTEVFEKILLLLDITKITVVFIFDEIDTFAG
PVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIY
MPQIQNLDDMVDAVRNLLTVRSEISPWVSQWNETLEKELSDPRSNLNRHI
RMNFETFRSLPTLKNSIIPLVATSKNFGSLCTAIKSCSFLDIYNKNQLSN
NLTGRLQSLSDLELAILISAARVALRAKDGSFNFNLAYAEYEKMIKAINS
RTIKLWLKKDVKNVWENLVQLDFFTEKSAVGLRDNATAAFYASNYQFQGT
MIPFDLRSYQMQIILQELRRIIPKSNMYYSWTQL
3D structure
PDB7tjh A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
ChainD
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D R478 Y486 Y490 F492 Q493 R383 Y391 Y395 F397 Q398
BS02 ATP D R104 Q105 S106 Y107 K108 T109 Y110 D113 R59 Q60 S61 Y62 K63 T64 Y65 D68
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7tjh, PDBe:7tjh, PDBj:7tjh
PDBsum7tjh
PubMed35217664
UniProtP54791|ORC4_YEAST Origin recognition complex subunit 4 (Gene Name=ORC4)

[Back to BioLiP]